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Psychothérapies pour le trouble bipolaire et la dépression
ARTICLES
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Association of Suicidal Status, Inflammation Markers, and Resting-State Functional Activity and Connectivity in Patients With Major Depressive Disorder
J Clin Psychiatry. 2024 Jun 26;85(3):23m15148. doi: 10.4088/JCP.23m15148.ABSTRACTAbstract.Background: This study aimed to identify (1) neural markers of suicide attempt using resting-state functional magnetic resonance imaging (rs-fMRI) and (2) associations between rs-fMRI metrics and resting-state functional connectivity (rs-FC), suicidal phenotype, and peripheral blood inflammation markers.Methods: Inflammation markers (C-reactive protein [CRP], …
Impact of cariprazine on body weight and blood pressure among adults with bipolar I disorder, schizophrenia, or major depressive disorder in a real-world setting
Ann Gen Psychiatry. 2025 Jan 27;24(1):5. doi: 10.1186/s12991-024-00542-w.ABSTRACTBACKGROUND: Atypical antipsychotics are a common treatment for serious mental illness, but many are associated with adverse effects, including weight gain and cardiovascular issues, and real-world experience may differ from clinical trial data. Cariprazine has previously demonstrated a favorable safety and …
The Effectiveness of Short-Term Group Psychoeducation for Patients With Bipolar Disorder in Japan
Cureus. 2024 Dec 26;16(12):e76441. doi: 10.7759/cureus.76441. eCollection 2024 Dec.ABSTRACTIntroduction Psychoeducation is a form of psychosocial treatment with proven efficacy in preventing the relapse of bipolar disorder (BD). However, the effectiveness of psychoeducation has not been verified in Japan. We aimed to examine the effect of a brief group psychoeducation course (eight-session …
Common Elements and Differences Among Treatment Approaches to Complex Post-Traumatic Stress Disorder: A Commentary on Five Case Studies
J Clin Psychol. 2025 Jan 27. doi: 10.1002/jclp.23773. Online ahead of print.ABSTRACTTreating people who have experienced deep and prolonged developmental trauma, that is, complex post-traumatic stress disorder (cPTSD), can be challenging given the complexity and severity of their presentations. The main features of complex post-traumatic stress disorder, that is, affective and …
Cyber abuse and posttraumatic stress disorder among racially diverse women who have resided in domestic violence shelters: A longitudinal approach
Psychol Trauma. 2025 Jan 27. doi: 10.1037/tra0001868. Online ahead of print.ABSTRACTOBJECTIVE: The present study presents a longitudinal examination of the impact of cyber abuse (CA) on posttraumatic stress disorder (PTSD) severity among a racially diverse sample of women with intimate partner violence (IPV).METHOD: Using data collected from a completed randomized …
A Bitter Pill: The Ethics of Involuntary Treatment of Adolescents With Severe Eating Disorders
Hosp Pediatr. 2025 Jan 27:e2024007921. doi: 10.1542/hpeds.2024-007921. Online ahead of print.ABSTRACTSevere eating disorders (EDs) are a common and increasing threat to normal adolescent health and development. Major clinical challenges include longstanding malnutrition potentially complicated by emergent electrolyte disorders and cardiac dysfunction. The care of adolescents with severe EDs can …
Phenomenology of Identity: Narrative Medicine Curricula in the Care of Eating Disorders
J Med Humanit. 2025 Jan 27. doi: 10.1007/s10912-025-09929-6. Online ahead of print.ABSTRACTA growing body of literature explores the intersection of eating disorders and identity formation-an entanglement that makes eating disorders particularly challenging to treat. Narrative medicine is a discipline of the health humanities that is interested in bearing …
Evaluating the Impact of a Safe Exercise Training on Clinician Knowledge and Self-Efficacy in Managing Dysfunctional Exercise in an Eating Disorder Treatment Setting
J Eval Clin Pract. 2025 Feb;31(1):e14319. doi: 10.1111/jep.14319.ABSTRACTINTRODUCTION: Dysfunctional exercise (DEX) is common among individuals with an eating disorder (ED) and poses significant challenges to treatment and recovery. While safe and nutritionally supported physical activity can enhance treatment outcomes without hindering weight restoration, clinicians often hesitate to address DEX …
Binge eating behaviours are associated with recurrent weight gain after metabolic and bariatric surgery
Clin Obes. 2025 Jan 27:e12735. doi: 10.1111/cob.12735. Online ahead of print.ABSTRACTBACKGROUND: Recurrent weight gain (RWG) is a major post-operative challenge among metabolic and bariatric surgery (MBS) patients. Binge eating behaviours (BEB) and food addiction (FA) have been identified as significant predictors of post-MBS RWG. However, limited research has investigated their …
Remediating cognitive inflexibility in obsessive compulsive disorder and anorexia nervosa neither moderates nor mediates treatment effects: an exploratory study
Front Psychiatry. 2025 Jan 13;15:1456890. doi: 10.3389/fpsyt.2024.1456890. eCollection 2024.ABSTRACTOBJECTIVE: Obsessive compulsive disorder (OCD) and anorexia nervosa (AN) are conditions associated with poor cognitive flexibility, a factor considered to interfere with treatment, but research into the relationship between cognitive flexibility and treatment outcome is limited. This study explores whether baseline measures of cognitive …
Comparing social stigma of anorexia nervosa, bulimia nervosa, and binge-eating disorder: A quantitative experimental study
J Eat Disord. 2025 Jan 27;13(1):15. doi: 10.1186/s40337-025-01198-x.ABSTRACTBACKGROUND: Currently, we know little regarding how stigma attributed to eating disorders compares to that of other psychological disorders and additionally within different types of eating disorders. In the current study, we aimed to explore the stigmatisation of eating disorders by …
A systematic review of the clinical practice guidelines for the assessment, management and treatment of eating disorders during the perinatal period
BMC Pregnancy Childbirth. 2025 Jan 28;25(1):82. doi: 10.1186/s12884-024-06995-x.ABSTRACTBACKGROUND: Eating disorders during the perinatal period can pose significant risks to both the mother and the baby. Clinical practice guidelines include statements of expected practice intending to improve effectiveness and quality of care within health care services. This systematic review …
Soins Psychiatr. 2024 Mar-Apr;45(351):20-25. doi: 10.1016/j.spsy.2024.01.008. Epub 2024 Mar 6.ABSTRACTThe majority of teenagers benefit from scientific advances, whether pharmacological or technological, but the most vulnerable use them to their detriment. While only certain substances or activities are potentially "addictive", the psyche, personality and environment play a major role in the …
Effectiveness of psychotherapy on dissociative symptoms in adult populations: A PRISMA systematic review
Encephale. 2024 Dec;50(6):670-681. doi: 10.1016/j.encep.2024.01.001. Epub 2024 Mar 23.ABSTRACTINTRODUCTION: Dissociation is a psychological process in reaction to threat which can be found in many psychiatric conditions. Dissociative symptoms can become very disabling, whether in daily life or in care. Nevertheless, few studies seem to have examined the efficacy of psychotherapy …
Évaluation du processus d’annonce de diagnostic de trouble de personnalité état-limite : audit clinique dans un service ambulatoire pour jeunes adultes
Rech Soins Infirm. 2024;155(4):37-49.ABSTRACTINTRODUCTION: Borderline personality disorder is a commonly encountered disorder in psychiatry. This diagnosis is rarely given despite the benefits of its disclosure. Recommendations concerning diagnosis disclosure in psychiatry have recently been published. An analysis of the disclosure process in an outpatient team for young adults enables …
Court-ordered inpatient psychiatric care in Switzerland. Length of stay and treatment outcome
Rev Med Suisse. 2024 Feb 21;20(862):410-413. doi: 10.53738/REVMED.2024.20.862.410.ABSTRACTMentally disordered offenders may be convicted to court-ordered psychiatric-psychotherapeutic inpatient care. Based on the concept of a forensic therapeutic community, the treatments of 204 inmates of a medium-security hospital, who presented with psychosis, personality disorders or substance-use disorders, have been assessed. After a median …
Neuropeptide Y in first-episode schizophrenia: is there any sex differences in the pathogeneses of schizophrenia?
Front Psychiatry. 2024 Dec 3;15:1514475. doi: 10.3389/fpsyt.2024.1514475. eCollection 2024.ABSTRACTOBJECTIVE: This study investigated relationships between Neuropeptide Y levels and severity of psychiatric symptoms in first-episode schizophrenia patients, and explore the sexual heterogeneity in them.METHODS: We recruited 115 first-episode schizophrenia patients and 58 matched healthy controls, and measured serum Neuropeptide Y levels of them at …
Identification of serum metabolic traits of AIWG in first-episode schizophrenia patients
BMC Psychiatry. 2024 Dec 23;24(1):946. doi: 10.1186/s12888-024-06413-8.ABSTRACTBACKGROUND: Antipsychotic-induced weight gain (AIWG) is a common side effect of antipsychotic drugs and may lead to cardiometabolic comorbidities. There is an urgent public health need to identify patients at high risk of AIWG and determine potential biomarkers for AIWG.METHODS: In …
Cost-effectiveness of ten commonly used antipsychotics in first-episode schizophrenia in the UK: economic evaluation based on a de novo discrete event simulation model
Br J Psychiatry. 2024 Dec 26:1-8. doi: 10.1192/bjp.2024.251. Online ahead of print.ABSTRACTBACKGROUND: Previous economic evidence about interventions for schizophrenia is outdated, non-transparent and/or limited to a specific clinical context.AIMS: We developed a de novo discrete event simulation (DES) model for estimating the cost-effectiveness of interventions in schizophrenia in …
Peripheral blood complement factors C2 and C3 as biomarkers of clinical efficacy in patients with first-episode schizophrenia after aripiprazole treatment
BMC Psychiatry. 2024 Dec 31;24(1):961. doi: 10.1186/s12888-024-06437-0.ABSTRACTOBJECTIVE: The objective of this study was to identify serum complement factor-based biomarkers indicative of clinical efficacy in patients with first-episode schizophrenia (SCZ) following treatment with aripiprazole.METHODS: The retrospective study cohort comprised 40 patients diagnosed with first-episode SCZ (SCZ group) and 40 healthy …
Aberrant Cortical Morphological Networks in First-Episode Schizophrenia
Schizophr Bull. 2025 Jan 6:sbae218. doi: 10.1093/schbul/sbae218. Online ahead of print.ABSTRACTBACKGROUND AND HYPOTHESIS: Population-based morphological covariance networks are widely reported to be altered in schizophrenia. Individualized morphological brain network approaches have emerged recently. We hypothesize that individualized morphological brain networks are disrupted in schizophrenia.STUDY DESIGN: We constructed single-subject …
Psychopathology trajectories and relapse in first episode schizophrenia with assured long-acting injectable adherence over 24 months
Schizophr Res. 2025 Jan 16;276:8-14. doi: 10.1016/j.schres.2025.01.007. Online ahead of print.ABSTRACTBACKGROUND: Relapse following a first episode of schizophrenia (FES) is common and often results in serious adverse psychosocial consequences. Treatment non-adherence is a key risk factor for relapse, but why relapse occurs despite antipsychotic treatment adherence remains unclear. This …
Peripheral tryptophan-kynurenine pathway dysfunction in first-episode schizophrenia
Sci Rep. 2025 Jan 18;15(1):2432. doi: 10.1038/s41598-025-86390-4.ABSTRACTThe tryptophan (TRP)-kynurenine (KYN) pathway is involved in the pathogenesis of schizophrenia. This study aimed to investigate the levels of TRP-KYN metabolites in serum and urine of patients with first-episode schizophrenia (FES) and their association with clinical manifestations. This study included 38 …
Comparative effectiveness of antipsychotic treatment strategies for relapse prevention in first-episode schizophrenia in Finland: a population-based cohort study
Lancet Psychiatry. 2025 Feb;12(2):122-130. doi: 10.1016/S2215-0366(24)00366-3.ABSTRACTBACKGROUND: The best pharmacological treatment practices for relapse prevention in patients with first-episode schizophrenia are unclear. We aimed to assess different treatment strategies used before and after the first relapse, and their associations with subsequent relapse risk.METHODS: In this population-based cohort …
Adiponectin, resistin, interleukin-4 and TGF-beta2 levels in treatment resistant schizophrenia patients
Prog Neuropsychopharmacol Biol Psychiatry. 2025 Jan 10;136:111221. doi: 10.1016/j.pnpbp.2024.111221. Epub 2024 Dec 17.ABSTRACTBACKGROUND: The aim of the present study was to measure adiponectin, resistin, interleukin-4 and TGF-β levels in first episode, treatment resistant patients with schizophrenia.METHODS: In total, fifty-three treatment-resistant patients were included in the study. In subgroups of these patients, …
Effect of Organic Anion Transporting Polypeptide 1B1 on Plasma Concentration Dynamics of Clozapine in Patients with Treatment-Resistant Schizophrenia
Int J Mol Sci. 2024 Dec 9;25(23):13228. doi: 10.3390/ijms252313228.ABSTRACTThe involvement of drug-metabolizing enzymes and transporters in plasma clozapine (CLZ) dynamics has not been well examined in Japanese patients with treatment-resistant schizophrenia (TRS). Therefore, this clinical study investigated the relationship between single nucleotide polymorphisms (SNPs) of various pharmacokinetic factors (drug-metabolizing enzymes and …
Consistent frontal-limbic-occipital connections in distinguishing treatment-resistant and non-treatment-resistant schizophrenia
Neuroimage Clin. 2024 Dec 12;45:103726. doi: 10.1016/j.nicl.2024.103726. Online ahead of print.ABSTRACTBACKGROUND AND HYPOTHESIS: Treatment-resistant schizophrenia (TR-SZ) and non-treatment-resistant schizophrenia (NTR-SZ) lack specific biomarkers to distinguish from each other. This investigation aims to identify consistent dysfunctional brain connections with different atlases, multiple feature selection strategies, and several classifiers in distinguishing TR-SZ …
Addressing brain metabolic connectivity in treatment-resistant schizophrenia: a novel graph theory-driven application of (18)F-FDG-PET with antipsychotic dose correction
Schizophrenia (Heidelb). 2024 Dec 19;10(1):116. doi: 10.1038/s41537-024-00535-4.ABSTRACTFew studies using Positron Emission Tomography with 18F-fluorodeoxyglucose (18F-FDG-PET) have examined the neurobiological basis of antipsychotic resistance in schizophrenia, primarily focusing on metabolic activity, with none investigating connectivity patterns. Here, we aimed to explore differential patterns of glucose metabolism between patients and …
Response to clozapine in treatment resistant schizophrenia is related to alterations in regional cerebral blood flow
Schizophrenia (Heidelb). 2024 Dec 23;10(1):122. doi: 10.1038/s41537-024-00544-3.ABSTRACTPET and SPECT studies in treatment-resistant schizophrenia (TRS) have revealed significant alterations in regional cerebral blood flow (CBF) during clozapine treatment, which may vary according to the clinical response. Here, we used the more recent MRI approach of arterial spin labelling (ASL) …
Genetic risk for treatment resistant schizophrenia and corresponding variation in dopamine synthesis capacity and D(2/3) receptor availability in healthy individuals
Mol Psychiatry. 2024 Dec 27. doi: 10.1038/s41380-024-02873-2. Online ahead of print.ABSTRACTDysfunction of dopamine systems has long been considered a hallmark of schizophrenia, and nearly all current first-line medication treatments block dopamine D2 receptors. However, approximately a quarter of patients will not adequately respond to these agents and are …
Response to clozapine and its predictors in treatment-resistant schizophrenia spectrum disorders: A retrospective chart review
Schizophr Res. 2025 Jan;275:179-188. doi: 10.1016/j.schres.2024.12.015. Epub 2024 Dec 31.ABSTRACTThe response rate to clozapine in patients with treatment-resistant schizophrenia spectrum disorders (TRSS) is around 40 %. But, in general, a better prognosis is noted for schizophrenia in developing countries, including India. Given the scarcity of related literature from India, this study aimed …
Bioethics in Morocco: An example of research on schizophrenia and the history of the Casablanca biomedical research ethics committee
Encephale. 2025 Feb;51(1S):S13-S16. doi: 10.1016/j.encep.2024.11.002. Epub 2024 Dec 13.ABSTRACTThe ethics committee for biomedical research of Casablanca (CERBC) was born within the Faculty of Medicine and Pharmacy of Casablanca (FMPC) in Morocco in 1989, following the impetus of some teachers who were aware, from their specialties and their concerns, to …
Systematic review of parenteral ketamine for managing acute agitation in emergency settings
Asian J Psychiatr. 2025 Jan;103:104344. doi: 10.1016/j.ajp.2024.104344. Epub 2024 Dec 12.ABSTRACTINTRODUCTION: Agitation, a significant psychiatric issue often linked to conditions like schizophrenia, bipolar disorder, and major depression, invariably pose challenges in emergency settings. Acute agitation occurs in 2.6 % of emergency cases and up to 12.2 % among patients with schizophrenia or bipolar disorder. With …
Violence risk prediction in mental health inpatient settings using the Dynamic Appraisal of Situational Aggression
Front Psychiatry. 2024 Dec 10;15:1460332. doi: 10.3389/fpsyt.2024.1460332. eCollection 2024.ABSTRACTINTRODUCTION/BACKGROUND: Aggression and violence are common problems in healthcare settings and affects both patients and healthcare staff. The Dynamic Appraisal of Situational Aggression (DASA) is an assessment tool to guide assessment for short term risk in inpatient settings. There have been no large-scale …
Exploring Stigma Towards People with Schizophrenia in Mass Media and Their Private Discourses
Rev Colomb Psiquiatr (Engl Ed). 2024 Oct-Dec;53(4):471-479. doi: 10.1016/j.rcpeng.2024.12.004.ABSTRACTINTRODUCTION: It has been shown that public stigma towards people with schizophrenia hinders their psychosocial integration. Public stigma expresses itself through lexical labels used in the print media and social networks, heightening the internalization of stigma in this population, a …
The historical synchronicities of the Eli Lilly Canada Chair on schizophrenia research
Sante Ment Que. 2024 Fall;49(2):271-295.ABSTRACTBackground Created in 2004, the Eli Lilly Canada Chair on schizophrenia research was funded by Eli Lilly, the Institut universitaire en santé mentale de Montréal, Hôpital Sacré-Coeur and Centre hospitalier de l'Université de Montréal. The aim of this article is to provide …
Psychothérapies pour le trouble bipolaire et la dépression
Therapeutic Potential of MDMA- and Psychedelic-Assisted Psychotherapy for Adolescent Depression and Trauma
Curr Psychiatry Rep. 2025 Feb;27(2):88-97. doi: 10.1007/s11920-024-01577-2. Epub 2024 Dec 19.ABSTRACTPURPOSE OF REVIEW: There is a mental health crisis affecting youth, and the utility of existing treatments is often limited by lack of effectiveness and tolerability. The aim of this review is to report on outcomes of clinical …
The gain-of-function variant in the NLRP3 gene predicts the effectiveness of brief psychotherapy but not the risk of major depression
Behav Brain Res. 2025 Mar 12;481:115413. doi: 10.1016/j.bbr.2024.115413. Epub 2024 Dec 30.ABSTRACTMajor depressive disorder (MDD) is a highly prevalent psychiatric condition whose pathophysiology has been linked to neuroinflammatory processes involving the NLRP3 inflammasome. To address this point, the study investigated the association of the NLRP3 rs10754558 polymorphism with MDD diagnosis in a …
Evaluating virtual reality technology in psychotherapy: impacts on anxiety, depression, and ADHD
Front Psychiatry. 2024 Dec 18;15:1480788. doi: 10.3389/fpsyt.2024.1480788. eCollection 2024.ABSTRACTBACKGROUND: Mental health issues pose a significant challenge for medical providers and the general public. The World Health Organization predicts that by 2030, mental health problems will become the leading cause of global disease burden, highlighting the urgent need for effective mental health interventions. Virtual …
