Two Memos Issued Re: Severe Acute Hepatitis of Unknown Origin in Children
On April 26, 2022 the Office of the Chief Medical Officer of Health issued a memo to primary care providers notifying them that there have been 169 cases of severe acute hepatitis of unknown origin in children reported in Europe, Israel and the United States. The World Health Organization has issued alerts and a case definition.
On May 4, 2022 the Office of the Chief Medical Officer of Health issued a memo to notify of a class 77.6 order issued under the Health Protection and Promotion Act, requiring all public hospitals to report cases of severe acute hepatitis of unknown origin in children to Public Health Ontario (PHO). This is being done out of an abundance of caution, working collaboratively with the Public Health Agency of Canada and PHO. If a patient meets the probable or epi-linked case definition in Appendix A, the health care provider must contact Public Health Ontario at 647-260-7419 and fax the completed case report form to HPEPH at 613-966-1813. Please see the attached Order outlining the requirements for data collection, case definitions for probable and epi-linked cases, case reporting form, and further instructions regarding reporting and sharing information with PHO.
The Office of the Chief Medical Officer of Health is requesting clinicians to be vigilant with infants and children up to 16 years of age presenting with signs and symptoms compatible with acute hepatitis, including new onset of jaundice (yellow skin and/or eyes) and discolouration of urine (dark) and/or feces (pale).
Considering the appropriate clinical context, other symptoms that may be suggestive of hepatitis include:
- pruritis
- arthralgia/myalgia
- fever
- nausea, vomiting or abdominal pain
- lethargy and or loss of appetite
For children presenting with symptoms compatible with acute hepatitis, timely laboratory testing is recommended including CBC, AST, ALT, GGT, direct and indirect bilirubin, albumin and INR.
If acute hepatitis is confirmed on laboratory testing, further laboratory work-up is recommended to assess for potential infectious and non-infectious etiologies as relevant to the clinical history. For pediatric patients with severe hepatitis of unknown etiology with AST or ALT > 500 U/L, adenovirus testing should be considered, which may include nasopharyngeal swab, stool and/or blood PCR, depending on laboratory test availability.
Test requisition for hepatitis of unknown origin in children - Public Health Ontario