Psychothérapies pour le trouble bipolaire et la dépression
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Reduced Slow-Wave Sleep and Sleep-Disordered Breathing Are Linked to Suicidal Ideation in Major Depressive Disorder
Brain Behav. 2026 Aug;16(8):e71693. doi: 10.1002/brb3.71693.ABSTRACTBACKGROUND: Suicidal ideation (SI) is common in major depressive disorder (MDD) and has been linked to sleep disturbances. However, the relative contributions of subjective sleep quality and objective sleep architecture to SI remain unclear.METHODS: A total of 103 inpatients with MDD underwent polysomnography (PSG) …
IL-1alpha and CRP as key inflammatory mediators linking neuropathic pain, anxiety, and depression in major depressive disorder
BMC Psychiatry. 2026 Aug 17;26(1):634. doi: 10.1186/s12888-026-08351-z.ABSTRACTBACKGROUND: It's common comorbidity for Major Depressive Disorder (MDD), anxiety, and pain, underpinned by shared chronic inflammatory processes, this study aimed to identify etiological inflammatory biomarkers, focusing on MDD individuals with anxiety and pain symptoms.METHODS: Initially, 218 participants underwent screening for this …
Heart rate variability reactivity moderates the relationship between behavioral disinhibition and suicide attempts in mood disorders
J Affect Disord. 2026 Jul 20:122285. doi: 10.1016/j.jad.2026.122285. Online ahead of print.ABSTRACTBACKGROUND: Distinguishing suicide attempters from those with only ideation remains a major clinical challenge. This study investigated whether heart rate variability (HRV) reactivity, a marker of autonomic regulation, moderates the relationship between behavioral disinhibition and suicide attempts.METHODS: We …
Comorbidity Between Mood Disorders and Chronic Somatic Diseases, With a Focus on Cardiometabolic Disease, and Its Mechanistic Crosstalk
Depress Anxiety. 2026 Jul 24;2026:7688691. doi: 10.1155/da/7688691. eCollection 2026.ABSTRACTThe comorbidity of mood disorders (MDs), represented by depression and anxiety, with chronic somatic diseases (CDs), particularly cardiometabolic conditions, poses a significant global public health challenge, markedly increasing the risk of adverse prognoses and all-cause mortality. Epidemiological studies indicate that ~36% of patients with multimorbidity …
Factors Associated with Treatment Dropout in Patients with Mood Disorders
Clin Psychopharmacol Neurosci. 2026 Aug 31;24(3):641-649. doi: 10.9758/cpn.26.1458.ABSTRACTOBJECTIVE: Treatment dropout is common among patients with mood disorders and adversely affects long-term outcomes. This study investigated clinical and psychological factors associated with dropout, with a particular focus on stress coping strategies.METHODS: This retrospective cohort study included 321 patients with mood disorders …
Next-generation precision medicine for mood disorders: reproducible blood biomarkers enable objective diagnostics, subtyping, and targeted therapeutics
Mol Psychiatry. 2026 Aug 4. doi: 10.1038/s41380-026-03736-8. Online ahead of print.ABSTRACTMood disorders are highly prevalent in society, often disabling, and can lead to a reduced healthspan and lifespan, including by suicide. Depression and bipolar disorders are currently deemed to be chronic and/or treatment-refractory in up to half …
Short-chain fatty acid-producing psychobiotics in mood disorders: mechanistic insights into the microbiota-gut-brain axis
Clin Nutr Res. 2026 Jun;15(3):211-227. doi: 10.7762/cnr.2026.0016. Epub 2026 Jul 31.ABSTRACTMood disorders, including major depressive disorder, bipolar disorder, generalized anxiety disorder, and posttraumatic stress disorder, constitute a primary source of global disability, and with conventional monoamine-targeted pharmacotherapy, approximately one-third of patients remain with treatment-resistant disease. Over the past decade, the microbiota-gut-brain …
Diagnostic delays and suicidal thoughts and behaviors among young adults with a history of mood disorders
Front Psychiatry. 2026 Jul 22;17:1894148. doi: 10.3389/fpsyt.2026.1894148. eCollection 2026.ABSTRACTINTRODUCTION: Suicidal thoughts and behaviors (STBs) are prevalent among young adults with mood disorders. This study examined whether length of diagnostic delay was independently associated with risk for STBs.MATERIALS AND METHODS: Data were from a national online survey of US adults ages 18-35 …
Anxiety and mood disorders from childhood to adulthood in very preterm and term-born individuals
Pediatr Res. 2026 Aug 15. doi: 10.1038/s41390-026-05377-7. Online ahead of print.ABSTRACTBACKGROUND: Very preterm (VP) birth has been associated with higher rates of anxiety and mood disorders, but the emergence and persistence from childhood to adulthood is unknown. This study examined prevalence rates and early risk factors of these …
A Novel Approach to the Involvement of Loved Ones in the Treatment of Individuals with Eating Disorders: The Family Integration Model
Behav Sci (Basel). 2026 Jun 24;16(7):1049. doi: 10.3390/bs16071049.ABSTRACTThe purpose of this study was to describe a novel approach to involving family members and support people in higher-level care treatment for patients with eating disorders (EDs) across the age spectrum, to examine outcomes on ED symptoms, depression, and anxiety, and to assess …
Behav Sci (Basel). 2026 Jul 11;16(7):1174. doi: 10.3390/bs16071174.ABSTRACTA dearth of information exists on differences in quality of life across eating disorder diagnoses. The purpose of the current study was to examine quality of life among a large sample of adults with one of six eating disorder diagnoses: anorexia nervosarestricting subtype (AN-R), …
Insulin-Related Disordered Eating Behaviour: A Scoping Review of Evidence
Curr Diab Rep. 2026 Jul 29;26(1):23. doi: 10.1007/s11892-026-01637-2.ABSTRACTPURPOSE OF REVIEW: Current understanding of insulin-related disordered eating behaviour is limited by inconsistencies in terminology and measurement. Prevalence of the behaviour and characteristics of individuals are unclear. How best to intervene and with whom is therefore unknown. This scoping review …
The Weight of the Number: Perceptions and Practices Surrounding Expected Body Weight Disclosure in Eating Disorder Treatment
Int J Eat Disord. 2026 Aug 2. doi: 10.1002/eat.70184. Online ahead of print.ABSTRACTOBJECTIVE: Expected body weight (EBW) determination is common in eating disorder (ED) treatment, yet no evidence-based guidelines exist for how to discuss EBWs with patients. Clinicians have previously conceptualized these discussions as therapeutic exposures targeting fear of weight gain. …
Women's eating disorder origins as responses to childhood trauma and negative social self: a qualitative study exploring lived experience perspectives
J Eat Disord. 2026 Aug 4;14(1):175. doi: 10.1186/s40337-026-01656-0.ABSTRACTBACKGROUND: Research has identified many risk factors, ranging from individual to sociocultural believed to contribute to the development of eating disorders. However, the majority of studies are quantitative and tend to focus on anorexia nervosa exclusively, while prioritizing the voices of …
Soins Psychiatr. 2026 Jul-Aug;47(365):22-25. doi: 10.1016/j.spsy.2026.04.006. Epub 2026 Jul 6.ABSTRACTThe treatment of anorexia nervosa is often a long-term process, involving a series of care stages both in and out of the hospital. The presentation of the clinical case of a patient who has become a volunteer peer supporter reflects a …
Brain Sci. 2026 Jul 13;16(7):741. doi: 10.3390/brainsci16070741.ABSTRACTBackground/Objectives: The rates of obesity and binge-eating disorder (BED) have increased markedly over the last few decades. The onset of these conditions has been associated in part with the disruption of neural pathways that regulate food reward. Existing literature has implicated the endogenous opioid …
Motivation to Change, Therapeutic Alliance and Outcome-A Complex Interaction in Patients With Anorexia Nervosa
Int J Eat Disord. 2026 Aug 11. doi: 10.1002/eat.70189. Online ahead of print.ABSTRACTOBJECTIVE: The role of the therapeutic alliance (TA) in treatment outcomes of anorexia nervosa (AN) appears to be less substantial than in other disorders. However, the therapeutic process is a complex trajectory with many variables influencing each other. Hence, …
Trajectories of blood parameters and body weight during inpatient treatment of anorexia nervosa with extreme underweight
J Eat Disord. 2026 Aug 12;14(1):186. doi: 10.1186/s40337-026-01734-3.ABSTRACTBACKGROUND: Laboratory parameters and body weight are objective markers of physical stability in patients with severe and extreme anorexia nervosa. However, systematic analyses of trajectories during inpatient treatment with high-calorie refeeding and prophylactic phosphate supplementation remain limited in extremely underweight persons. …
Associations Between Social Appearance Anxiety, Disordered Eating Attitudes, and Orthorexia Nervosa: A Cross-Sectional Study
Brain Behav. 2026 Aug;16(8):e71690. doi: 10.1002/brb3.71690.ABSTRACTOBJECTIVE: Disordered eating attitudes and orthorexia nervosa (ON) represent important public health concerns. Social appearance anxiety may constitute a key psychological factor underlying these patterns. This study aimed to examine social appearance anxiety as associated with disordered eating attitudes and ON in a large …
Reinforcement Learning in Eating Disorders: Clinical, Cognitive, and Metabolic Correlates
Eur Eat Disord Rev. 2026 Aug 17. doi: 10.1002/erv.70164. Online ahead of print.ABSTRACTOBJECTIVE: Reinforcement learning has been implicated in eating disorders, but findings remain inconsistent. This study compared reinforcement learning performance in anorexia nervosa (AN), bulimia nervosa (BN), and healthy controls (HC) using the Probabilistic Reward Task (PRT), and explored clinical, …
Behind the 'Social mask': a phenomenological study of loneliness and social disconnection in women with Eating disorders
Eat Disord. 2026 Aug 18:1-19. doi: 10.1080/10640266.2026.2719843. Online ahead of print.ABSTRACTEating disorders (EDs) are chronic psychiatric conditions characterized by significant impairments in psychosocial functioning. This study utilizes an interpretative phenomenological analysis (IPA) to explore the lived experiences of social functioning and loneliness among women diagnosed with Eating Disorders (n = 8). Semi-structured interviews …
Eating Disorder Diagnostic Crossover: A Meta-Analysis
Int J Eat Disord. 2026 Aug 17. doi: 10.1002/eat.70175. Online ahead of print.ABSTRACTOBJECTIVE: Diagnostic crossover among eating disorders (EDs) is clinically important, yet rates are inconsistently quantified. This meta-analysis aims to quantify the frequency and direction of diagnostic crossover among EDs (both within-syndrome and between-syndrome), to evaluate study-level moderators of crossover …
Two operationalizations of a single construct: Overlap between borderline personality disorder and the level of personality functioning
Personal Disord. 2026 Jul 23. doi: 10.1037/per0000780. Online ahead of print.ABSTRACTScholarly debate continues regarding whether borderline personality disorder (BPD) represents a distinct categorical disorder or primarily reflects elevated levels of personality functioning (LPFs) as conceptualized in the Diagnostic and Statistical Manual of Mental Disorders, fifth ed., Alternative Model of Personality Disorders. …
Characterizing brain structural and functional abnormalities in borderline personality disorder by seed-based d mapping approach
Brain Imaging Behav. 2026 Jul 29;20(4):114. doi: 10.1007/s11682-026-01182-2.ABSTRACTBorderline personality disorder (BPD) is a mental disorder characterized by extreme instability in mood, interpersonal relationships, self-image, and behavioral patterns. Its core symptoms include intense mood swings, strained interpersonal relationships, disturbed self-identity, impulsive behaviors, and cognitive and perceptual abnormalities. The etiology …
Eye-Tracking and Borderline Personality Disorder: A Systematic Review
Brain Sci. 2026 Jul 1;16(7):712. doi: 10.3390/brainsci16070712.ABSTRACTBackground/Objectives: Borderline personality disorder (BPD) is a severe mental disorder characterised by emotion dysregulation, impulsivity and interpersonal hypersensitivity. Its prevalence ranges from 0.5% to 6.4%. Eye tracking and pupillometry provide objective indices of social attention and inhibitory control, but the BPD literature using these techniques has …
Minimal Emotional Dysfunctions (MED) in Personality Disorders: A Narrative Review
J Pers Disord. 2026 Aug;40(4):374-389. doi: 10.1521/pedi.2026.40.4.374.ABSTRACTEmotional dysfunctions are fundamental to understanding personality disorders (PDs). The Minimal Emotional Dysfunctions (MED) model offers a systematic approach by categorizing these dysfunctions into disorders of affect modulation, production, and quality. It posits that PDs are primarily emotional disorders, with emotional disturbances shaping …
Genome-wide association analyses of borderline personality disorder identify 11 loci and highlight shared risk with mental and somatic disorders
Nat Genet. 2026 Jul 20. doi: 10.1038/s41588-026-02654-3. Online ahead of print.ABSTRACTBorderline personality disorder (BPD) is a severe mental health condition influenced by environmental risk factors (for example, interpersonal trauma) and genetic factors. We conducted the largest genome-wide association study (GWAS) meta-analysis of BPD so far, with a discovery …
Beyond Borderline Personality Disorder: An Analysis of Emotional Dysregulation Through a Complex Case
Sante Ment Que. 2026 Spring;51(1):281-292.ABSTRACTEmotional dysregulation is often quickly attributed to Borderline Personality Disorder (BPD), particularly when repeated emergency department visits are involved. This case study illustrates the importance of a comprehensive, interdisciplinary assessment when the clinical presentation is complex. Johanne (fictional name), a woman in her forties with …
"Someone catching me when I'm falling": a qualitative study exploring satisfaction in romantic relationships where one partner has borderline personality disorder
Front Psychiatry. 2026 Jul 20;17:1807149. doi: 10.3389/fpsyt.2026.1807149. eCollection 2026.ABSTRACTINTRODUCTION: Interpersonal difficulties are a core challenge experienced by people who have borderline personality disorder (BPD). Relationships where one person has BPD are often rated lower in satisfaction than others due to their tumultuous and unstable nature. Interpersonal difficulties not only cause distress but …
Testosterone in patients with borderline personality disorder: from hair analyses to social behavior
Compr Psychoneuroendocrinol. 2026 Jul 27;27:100371. doi: 10.1016/j.cpnec.2026.100371. eCollection 2026 Aug.ABSTRACTClemens Kirschbaum provided the important inspiration for our team to extend the assessment of steroid hormones beyond blood and saliva samples to include hair analyses. This enabled the investigation of the effects of long-term, cumulative steroid hormone secretion. This novel methodological perspective …
Associations Between Dissociation and Childhood Trauma in Borderline Personality Disorder and Affective Disorders: A Network Analytic Approach
Acta Psychiatr Scand. 2026 Aug 9. doi: 10.1111/acps.70131. Online ahead of print.ABSTRACTBACKGROUND: Dissociation and childhood trauma are strongly associated with borderline personality disorder (BPD), yet it remains unclear whether this reflects disorder-specific mechanisms or differences in symptom severity within a shared transdiagnostic structure.OBJECTIVE: Using network analysis, we examined whether the …
Experiences of loneliness among people with a diagnosis of 'personality disorder': A qualitative interview study in the UK
PLOS Ment Health. 2026 Aug 10;3(8):e0000671. doi: 10.1371/journal.pmen.0000671. eCollection 2026.ABSTRACTLoneliness is common among people diagnosed with a 'personality disorder' and addressing this is a recovery goal. Little qualitative research has explored the experience of loneliness among people with a diagnosis of 'personality disorder'. This study aimed to provide an in-depth …
Personality disorders: what the neurologist should know
Pract Neurol. 2026 Aug 13:pn-2026-005213. doi: 10.1136/pn-2026-005213. Online ahead of print.ABSTRACTPersonality traits and disorders are frequently encountered in outpatient neurology. This can significantly influence the clinical consultation and the patient's neurological presentation and management. We offer practical guidance for neurologists to understand personality-related presentations better, along with clinical …
Localizing the structural and functional alteration networks associated with borderline personality disorder
J Affect Disord. 2026 Aug 14:122379. doi: 10.1016/j.jad.2026.122379. Online ahead of print.ABSTRACTBACKGROUND: Although structural and functional alterations in borderline personality disorder (BPD) have been widely reported in neuroimaging studies, the findings remain heterogeneous. Emerging consensus suggests that these distributed alterations may converge on a common pathological network associated with BPD, …
AKuT outpatient clinic: cross-sectoral crisis intervention for borderline personality disorder and trauma-related disorders at the Central Institute of Mental Health in Mannheim
Nervenarzt. 2026 Aug 17. doi: 10.1007/s00115-026-02007-9. Online ahead of print.ABSTRACTBACKGROUND: Patients with borderline personality disorder or trauma-related disorders often experience psychosocial crises. Due to a lack of promptly available outpatient treatment options, acute care is often provided in a psychiatric emergency department or an inpatient setting. This impedes …
Moderating Factors for the Effectiveness of Brief Psychological Intervention for People With Probable Personality Disorder: Secondary Analysis of Data From the SPS Trial
Personal Ment Health. 2026 Aug;20(3):e70096. doi: 10.1002/pmh.70096.ABSTRACTBrief interventions have been proposed as a means of increasing access to psychological treatment for people with personality disorder. However, evidence of their effectiveness is limited to date. A recent large-scale trial of Structured Psychological Support (SPS) for people with probable personality disorder …
Alterations in static and dynamic intrinsic brain local connectivity and associated molecular analysis in drug-naive first-episode schizophrenia: Insights from resting-state functional magnetic resonance imaging
Prog Neuropsychopharmacol Biol Psychiatry. 2026 Jul 27:111863. doi: 10.1016/j.pnpbp.2026.111863. Online ahead of print.ABSTRACTSchizophrenia is a severe psychiatric disorder marked by widespread brain abnormalities. Recent studies suggest that pathological changes may originate from focal 'epicenter' regions and subsequently spread to other brain areas strongly connected to them. Investigating drug-naïve first-episode …
Medium-term prediction of clinically relevant outcomes in first-episode schizophrenia patients
Schizophr Res. 2026 Aug 4;297:89-96. doi: 10.1016/j.schres.2026.07.027. Online ahead of print.ABSTRACTBACKGROUND: Predicting long-term outcomes in first-episode schizophrenia (FES) remains difficult, despite being especially important early in the illness, when timely intervention is most critical. It also remains unclear how much data from the initial phase of illness is required …
Associations among stress perception, clinical symptoms, and hippocampal subfield volumes in first-episode patients with schizophrenia
Front Psychiatry. 2026 Jul 23;17:1885091. doi: 10.3389/fpsyt.2026.1885091. eCollection 2026.ABSTRACTBACKGROUND: Hippocampal neurogenesis shapes adaptation and improves responses to stress. Patients with schizophrenia show marked functional impairment and abnormal stress sensitivity. However, it remains unclear how structural abnormalities in specific hippocampal subregions are related to altered perceived stress and clinical symptoms in schizophrenia.METHODS: …
Childhood trauma, specifically emotional abuse, is associated with psychiatric symptom severity in drug-naive first-episode patients with schizophrenia
Sci Rep. 2026 Jul 23;16(1):24736. doi: 10.1038/s41598-026-63324-2.ABSTRACTSchizophrenia (SCZ) is a highly heterogeneous disorder. Childhood trauma (CT) is a well‑established risk factor, although the contribution of specific CT dimensions remains incompletely understood. This study systematically investigated which CT dimensions were most strongly associated with symptom severity in drug‑…
Divergent cortical-subcortical intrinsic neural timescales in first-episode drug-naive or minimally treated schizophrenia
Asian J Psychiatr. 2026 Aug 7;123:105112. doi: 10.1016/j.ajp.2026.105112. Online ahead of print.ABSTRACTBACKGROUND: The neuropathological mechanisms of schizophrenia remain unclear. Intrinsic neural timescale (INT) reflects the temporal organization of neural activity. This study aimed to characterize INT alterations in patients with first-episode schizophrenia who were drug-naïve or minimally treated, while …
Trial-History Effects During WCST in Treatment-Resistant Schizophrenia
Neuropsychopharmacol Rep. 2026 Sep;46(3):e70151. doi: 10.1002/npr2.70151.ABSTRACTAIM: Treatment-resistant schizophrenia (TRS) is a clinically important subtype of schizophrenia, but its cognitive characteristics remain incompletely understood. The Wisconsin Card Sorting Test (WCST) is widely used to assess executive dysfunction in schizophrenia, although conventional summary analyses may overlook trial-by-trial behavioral adaptation. This study …
Alpha Frequency Dysrhythmia in Treatment-Resistant Schizophrenia: Associations with EEG Background Changes, Disorganized Symptoms, and Dissociation
Biomedicines. 2026 Jun 30;14(7):1480. doi: 10.3390/biomedicines14071480.ABSTRACTBackground: Treatment-resistant schizophrenia (TRS) affects approximately 20-30% of patients and is associated with significant disability. EEG abnormalities, particularly background slowing and disorganized alpha activity, have been reported in TRS, but the role of alpha rhythm instability-here termed alpha dysrhythmia-remains poorly understood. Objective: To compare the individual …
Neurotrophins and Matrix Metalloproteinases in Treatment-Resistant Schizophrenia: Effects of Electroconvulsive Therapy on Serum Biomarkers and Clinical Outcomes: A Preliminary Study
Biomedicines. 2026 Jul 8;14(7):1535. doi: 10.3390/biomedicines14071535.ABSTRACTBackground: Available data indicate that the development of refractory schizophrenia may result from neuroinflammation, dysregulation of neurotrophins and metalloproteinases (MMPs), oxidative stress (OS), and hormonal imbalance. Electroconvulsive therapy (ECT) is an effective therapeutic option for drug resistance, but its impact on brain-derived neurotrophic factor (BDNF) and …
The prospective incidence of treatment-resistant schizophrenia: analysis of the CATIE trial using the TRRIP consensus
BJPsych Open. 2026 Jul 20;12(4):e191. doi: 10.1192/bjo.2026.12041.ABSTRACTBACKGROUND: The true incidence of treatment-resistant schizophrenia (TRS) remains uncertain, largely because earlier studies relied on heterogeneous definitions and retrospective assessments. The Treatment Response and Resistance in Psychosis (TRRIP) consensus established standardised diagnostic criteria, but these have rarely been applied prospectively.AIMS: To estimate …
Neurodevelopmental Impact of Copy Number Variants in Patients With Treatment-Resistant Schizophrenia
Biol Res Nurs. 2026 Jul 24:10998004261471531. doi: 10.1177/10998004261471531. Online ahead of print.ABSTRACTCopy number variations (CNVs) are a major contributor to the etiology and phenotypic variability in schizophrenia. CNVs are also independently associated with certain neurological, cognitive, and behavioral conditions, yet their role in early neurodevelopment in the context of treatment-resistant schizophrenia remain …
Aust N Z J Psychiatry. 2026 Jul 19:48674261462755. doi: 10.1177/00048674261462755. Online ahead of print.ABSTRACTThe ANZJP 2026 schizophrenia guideline appropriately emphasises the importance of identifying treatment-resistant schizophrenia and the timely initiation of clozapine. However, despite clear guidance on when to commence clozapine, there remains comparatively limited direction regarding the systematic assessment and management of …
Drug-Resistant Psychosis in a Tuberous Sclerosis Patient Treated With Electroconvulsive Therapy
J ECT. 2026 May 27. doi: 10.1097/YCT.0000000000001285. Online ahead of print.ABSTRACTTuberous sclerosis complex (TSC) leads to the development of severe neuropsychiatric disorders (TAND), which do not respond to treatment (1). This paper focuses on a 17-year-old male with TSC and uncontrolled epilepsy, which started when he was 1 year old. The surgical removal …
Efficacy and safety of rTMS for global symptom severity, negative symptoms, and auditory hallucinations in treatment-resistant schizophrenia: a systematic review and meta-analysis
Front Psychiatry. 2026 Jul 24;17:1783758. doi: 10.3389/fpsyt.2026.1783758. eCollection 2026.ABSTRACTBACKGROUND: Treatment-resistant schizophrenia (TRS) affects up to one-third of individuals with schizophrenia and remains a major clinical challenge despite optimized pharmacotherapy. Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a neuro-modulatory intervention for refractory symptoms, yet evidence specific to TRS remains limited and …
Possible Improvement of Tardive Dyskinesia and Negative Symptoms With Lurasidone Augmentation in a Treatment-Resistant Schizophrenia Patient
Case Rep Psychiatry. 2026 Aug 11;2026:7121649. doi: 10.1155/crps/7121649. eCollection 2026.ABSTRACTTardive dyskinesia (TD) is a cluster of symptoms affecting orofacial, truncal, and extremity regions following prolonged exposure to antidopaminergic agents and may be life-threatening in severe cases. It is most commonly observed in patients receiving long-term antipsychotic treatment, such as individuals with schizophrenia. …
When virtual reality gives voice to silence: A case report of a patient with schizoaffective disorder and progressive bilateral deafness treated with Avatar therapy
Sante Ment Que. 2026 Spring;51(1):175-188.ABSTRACTAuditory verbal hallucinations (AVH) are a common and often debilitating symptom of psychotic disorders. Despite pharmacological treatments, approximately 30% of patients continue to experience resistant AVH. Avatar therapy (AT), a virtual reality therapy, is an innovative approach aimed at changing the relationship between the patient and …
Delusion of Fellatio and Multimodal Cenesthetic Hallucinations in Schizophrenia: Beyond the Incubus
Sante Ment Que. 2026 Spring;51(1):131-145.ABSTRACTBackground Hallucinations with sexual content, particularly cenesthetic and oral hallucinations, are rarely reported in the psychiatric literature despite their significant potential for distress and impact on therapeutic engagement. Case presentation We describe a 51-year-old woman presenting with a complex psychotic picture, including cenesthetic hallucinations experienced …
A Delusion That Crawls: Ekbom Syndrome in Schizophrenia
Sante Ment Que. 2026 Spring;51(1):119-129.ABSTRACTThe objective of this case report is to present a clinical challenge encountered by a patient followed at the Institut universitaire en santé mentale de Montréal (IUSMM) Psychotic Disorders Program: the coexistence of Ekbom syndrome and schizophrenia. Schizophrenia and Ekbom syndrome (delusional parasitosis) are 2 …
Spirituality and cortisol in people living with schizophrenia: An exploratory study
Sante Ment Que. 2026 Spring-Summer;51(2):31-51.ABSTRACTObjective Several factors can contribute to the recovery of people living with schizophrenia. According to service users living with schizophrenia, spirituality would be an important element in their recovery journey. Spirituality could serve as a coping mechanism to manage psychological stress. The objective of this …
Psychothérapies pour le trouble bipolaire et la dépression
The efficacy of antidepressant medication versus interpersonal psychotherapy for depression in middle-aged women: a systematic review and individual participant data meta-analysis
Arch Womens Ment Health. 2026 Jul 20;29(4):110. doi: 10.1007/s00737-026-01730-1.ABSTRACTPURPOSE: Depression is highly prevalent in middle-aged women (MAW), but head-to-head comparisons of first-line interventions in this population are scarce. This systematic review and individual participant data (IPD) meta-analysis examined the comparative efficacy of antidepressant medication (ADM) and interpersonal psychotherapy (…
MicroRNAs expression changes associated with trauma-focused psychotherapy efficacy in treatment-resistant depression: An exploratory study
Neurosci Appl. 2026 Jul 9;5:107020. doi: 10.1016/j.nsa.2026.107020. eCollection 2026.ABSTRACTEarly life stress (ELS) increases vulnerability to major depressive disorder (MDD) and treatment-resistant depression (TRD) through lasting neurobiological and epigenetic alterations. MicroRNAs (miRNAs), key post-transcriptional regulators of gene expression, are emerging as potential biomarkers linking environmental stressors and depression pathophysiology. This study employed …
Nurse-led Interpersonal Psychotherapy (IPT) for Perinatal Women With Depression and Anxiety
J Am Psychiatr Nurses Assoc. 2026 Jul 29:10783903261466151. doi: 10.1177/10783903261466151. Online ahead of print.ABSTRACTBACKGROUND: Depression is the leading cause of disability worldwide and disproportionately affects women during the perinatal period. Although Interpersonal Psychotherapy (IPT) is supported as an effective treatment, access to IPT in routine care remains limited.AIMS: This project implemented …
Anxiety and depression subtypes and their psychotherapy response: A network analysis of 33,675 patients
Psychol Med. 2026 Aug 10;56:e257. doi: 10.1017/S0033291726105480.ABSTRACTBACKGROUND: Major depressive disorder and generalized anxiety disorder frequently co-occur, leading to heterogeneous presentations that complicate diagnosis and treatment. While diagnostic categories often obscure symptom variability, network approaches offer a powerful way to examine how symptoms relate to one another within and across conditions. …
Preliminary non-randomized clinical trial of subcutaneous esketamine in treatment-resistant depression: Exploring adjunctive effects of ketamine-assisted psychotherapy
J Affect Disord. 2026 Aug 10:122369. doi: 10.1016/j.jad.2026.122369. Online ahead of print.ABSTRACTBACKGROUND: Ketamine is an effective rapid-acting treatment for treatment-resistant depression (TRD), producing antidepressant effects within hours of administration. Because it induces states of heightened neuroplasticity and psychological openness, psychotherapy may enhance its therapeutic effects.METHODS: This exploratory, nonrandomized, open-label …
Effectiveness of psychological therapies for depression and anxiety in adults with and without ADHD in England: a retrospective cohort study
Lancet Reg Health Eur. 2026 Aug 6;68:101798. doi: 10.1016/j.lanepe.2026.101798. eCollection 2026 Sep.ABSTRACTBACKGROUND: People with ADHD disproportionately experience depression and anxiety across the lifespan than people without. To date interventions have focused on managing ADHD. This study aimed to evaluate the effectiveness of therapies designed to alleviate depression and anxiety.METHODS: We …
