Veille d’hiver (publication en avril), couvrant les mois de janvier, février et mars
Veille d’hiver (publication en avril), couvrant les mois de janvier, février et mars
Troubles en santé mentale
Bulletin de veille de l'équipe de la bibliothèques du CIUSSS de l'Est-de-l'Île-de-Montréal
Découvrez tout ce que la bibliothèque du CEMTL peut vous offrir grâce à une présentation de nos services adaptée à vos besoins et ceux de votre équipe.
Psychothérapies pour le trouble bipolaire et la dépression
Si vous êtes un.e employé.e du CEMTL et que vous désirez accéder à un article qui n'est pas disponible en accès libre, vous pouvez nous contacter par courriel, ou en utilisant le lien suivant:
Neuroinflammation and the Female Brain: Sex-Specific Mechanisms Underlying Mood Disorders and Stress Vulnerability
Life (Basel). 2026 Jan 15;16(1):139. doi: 10.3390/life16010139.ABSTRACTWomen exhibit a higher prevalence of depression, anxiety, stress-related disorders, and autoimmune conditions compared to men, yet the biological mechanisms underlying this sex difference remain incompletely understood. Growing evidence identifies neuroinflammation as a central mediator of psychiatric vulnerability in women, shaped by interactions between sex …
Macromolecular Proton Fraction Reveals Divergent White Matter Myelination in Bipolar Disorder and Unipolar Recurrent Depression
Bioengineering (Basel). 2026 Jan 11;13(1):78. doi: 10.3390/bioengineering13010078.ABSTRACTRecurrent depressive disorder (RDD) and bipolar disorder (BD) are the most common affective disorders worldwide. However, the pathogenesis of these disorders remains far from understood. Macromolecular proton fraction (MPF) mapping is a sensitive and specific quantitative MRI method for the assessment of brain tissue myelination, …
Oral Dysbiosis and Neuroinflammation: Implications for Alzheimer's, Parkinson's and Mood Disorders
Microorganisms. 2026 Jan 8;14(1):143. doi: 10.3390/microorganisms14010143.ABSTRACTBACKGROUND: Growing evidence indicates that oral microbiome dysbiosis contributes to systemic inflammation, immune activation, and neural dysfunction. These processes may influence the onset and progression of major neuropsychiatric and neurodegenerative disorders. This review integrates clinical, epidemiological, and mechanistic findings linking periodontal pathogens and oral microbial imbalance …
Microglial Activation in Cerebrovascular Accidents and the Manifestation of Major Depressive Disorder: A Comprehensive Review
Brain Sci. 2025 Dec 31;16(1):63. doi: 10.3390/brainsci16010063.ABSTRACTEmerging evidence highlights a strong association between cerebrovascular accident (CVA) and major depressive disorder (MDD), mediated by immune dysregulation. Elevated levels of proinflammatory cytokines, reduced adaptive immune responses, altered immune cell composition, and increased microglial activation characterize this bidirectional relationship. Microglial activation appears to be …
Altered Plasma Endocannabinoids and Oxylipins in Adolescents with Major Depressive Disorders: A Case-Control Study
Nutrients. 2026 Jan 15;18(2):280. doi: 10.3390/nu18020280.ABSTRACTBackground: Pediatric Major Depressive Disorder (pMDD) is one of the leading causes of disability in adolescents. There is currently no single explanation that fully accounts for the cause of the disorder, but various factors, including dysregulation of the immune and stress responses, have been linked to …
Spinal Posture and Movement in Female Adolescents with Anorexia Nervosa
J Clin Med. 2026 Apr 16;15(8):3054. doi: 10.3390/jcm15083054.ABSTRACTBackground: Profound musculoskeletal alterations encompassing bones and soft tissues are common in people with anorexia nervosa (AN). This study aims to examine spinal posture and mobility in adolescents with AN, and to compare these outcomes with those obtained from normal-weight female controls. Methods: Spinal …
Bulimia Nervosa in Adolescents: Impact of Childhood and Adolescent Sexual Abuse History and the Mediating Role of Social Media
Int J Soc Psychiatry. 2026 Apr 24:207640261438840. doi: 10.1177/00207640261438840. Online ahead of print.ABSTRACTThe aim of this study was to analyze whether exposure to esthetic content aligned with beauty standards on social media mediates the relationship between a history of childhood/adolescent sexual abuse and bulimic symptomatology in adolescents, and whether sex moderates …
The Importance of Considering Personal Recovery for Eating Disorders
Eur Eat Disord Rev. 2026 Apr 21. doi: 10.1002/erv.70116. Online ahead of print.ABSTRACTOBJECTIVE: Definitions of recovery from eating disorders (EDs) have traditionally emphasised symptom reduction and functional restoration. However, growing research highlights the importance of integrating personal recovery, defined by self-acceptance, autonomy, and psychological wellbeing. This study explored the relationship between …
"Name it to tame it": piloting a narrative medicine clinical intervention for adolescents and young adults with anorexia nervosa
J Eat Disord. 2026 Apr 21. doi: 10.1186/s40337-026-01612-y. Online ahead of print.ABSTRACTPURPOSE: Anorexia nervosa (AN) is highly morbid, particularly in adolescence. Narrative-based interventions, which employ storytelling and self-reflection, have improved outcomes for patients with various conditions, but narrative medicine specifically has not been studied in adolescents with AN. …
Conceptualising trauma in eating disorders: a reflexive commentary on the role of neglect, iatrogenic harm, and epistemic injury
J Eat Disord. 2026 Apr 23;14(1):94. doi: 10.1186/s40337-026-01610-0.ABSTRACTWhile links between eating disorders and post-traumatic stress disorder are well established, dominant frameworks have tended to locate trauma primarily outside healthcare, offering limited tools for understanding how neglect, exclusion, coercive practices, and epistemic misrecognition within care may contribute to ongoing …
Sweet taste hedonic response in anorexia nervosa: connections with nutritional status and psychopathology
Eat Weight Disord. 2026 Apr 30. doi: 10.1007/s40519-026-01854-4. Online ahead of print.ABSTRACTPURPOSE: This study aimed at investigating whether taste sensitivity is reduced in patients with anorexia nervosa (AN) and at examining the relationship between sweet taste perception, anthropometric and psychopathological parameters.METHODS: In this case-control study, 15 female patients …
"I can lose sight of my own well-being because I'm just so focused on them": a qualitative investigation of eating disorder clinicians' experiences in England
J Eat Disord. 2026 May 2. doi: 10.1186/s40337-026-01615-9. Online ahead of print.ABSTRACTBACKGROUND: Work in eating disorder (ED) services presents unique challenges and rewards that may affect clinicians' work-related and personal wellbeing. However, research on ED clinician needs, views, and experiences is still sparse, despite major service changes since …
Artists and eating disorders: what do we know? A systematic review of the evidence and gaps
Eat Weight Disord. 2026 May 5. doi: 10.1007/s40519-026-01863-3. Online ahead of print.ABSTRACTOBJECTIVES: Although artists are often considered at higher risk for eating disorders (EDs), evidence remains limited. We therefore conducted a systematic review of ED occurrence, risk, body image concerns, and general psychopathology in artistic populations.METHOD: Following …
Transition to adulthood with an eating disorder-Current state of research and recommendations for successful transition
Nervenarzt. 2026 May 6. doi: 10.1007/s00115-026-01965-4. Online ahead of print.ABSTRACTBACKGROUND: The transition to adulthood poses particular challenges for healthcare systems. Eating disorders frequently occur during this developmental period and require continuity of care in order to achieve remission and to reduce the risk of relapses as well as …
Clinical Phenotypes and Neurobiology of Youth With Avoidant/Restrictive Food Intake Disorder (ARFID) Across Sex
Int J Eat Disord. 2026 May 6. doi: 10.1002/eat.70081. Online ahead of print.ABSTRACTOBJECTIVE: Avoidant/restrictive food intake disorder (ARFID) is an eating disorder characterized by persistent avoidant/restrictive eating unrelated to body image. Sex differences in clinical phenotypes and neurobiology of ARFID are understudied. We hypothesized that females with ARFID would …
Family member's perceived impact of anorexia nervosa and bulimia nervosa on family dynamics: a qualitative systematic review and meta-synthesis
Cad Saude Publica. 2026 May 1;42:e00181525. doi: 10.1590/0102-311XEN181525. eCollection 2026.ABSTRACTEating disorders configure a growing and complex public health issue which hinders implementing targeted policies. Global health policies emphasize tailored interventions for reducing eating disorders harms among vulnerable people. This systematic literature review and meta-synthesis interprets the synthesized findings from primary …
Recent Advances in Sleep and Circadian Characteristics in Eating Disorders: A Systematic Review of the Last Five Years (2020-2025)
Nat Sci Sleep. 2026 May 1;18:590618. doi: 10.2147/NSS.S590618. eCollection 2026.ABSTRACTPURPOSE: A high number of people affected by eating disorders also show severe sleep disturbances, as well as circadian rhythm disruptions. However, research is relatively limited, often yielding conflicting results, especially when comparing clinical populations to healthy controls. Few interventions currently integrate …
"It's been a very, very long and emotional journey, and the impact is huge": a reflexive thematic analysis exploring the experiences of parents of children and young people with ARFID
J Eat Disord. 2026 May 6. doi: 10.1186/s40337-026-01588-9. Online ahead of print.ABSTRACTBACKGROUND: Avoidant Restrictive Food Intake Disorder (ARFID) is a relatively newly classified eating disorder which can significantly impact physical health and psychosocial function. This qualitative study aimed to explore the lived experience of ARFID caregivers in order …
"Locked in my body, caught up in my mind": neural signatures of body image rumination in anorexia nervosa
Brain Res Bull. 2026 May 4:111918. doi: 10.1016/j.brainresbull.2026.111918. Online ahead of print.ABSTRACTOBJECTIVES: Body image is a multidimensional construct crucial to the development and maintenance of anorexia nervosa (AN). Cognitive-emotional mechanisms shaping body image, particularly AN patients' tendency to ruminate, remain insufficiently understood. This study investigated body-focused rumination using a novel …
Brexpiprazole in Combination With Sertraline and as Monotherapy in Posttraumatic Stress Disorder: A Full-Factorial Randomized Clinical Trial
J Clin Psychiatry. 2025 Feb 19;86(1):24m15577. doi: 10.4088/JCP.24m15577.ABSTRACTObjective: To investigate the efficacy, safety, and tolerability of brexpiprazole in combination with sertraline and as monotherapy for posttraumatic stress disorder (PTSD).Methods: The trial comprised a 1-week placebo run-in period followed by an 11-week, randomized, double-blind, active-referenced, placebo-controlled, parallel-arm treatment period (…
Improvement of emotional dysregulation, aggression, and self-harm among people treated within outpatient personality disorder mental health services. A large longitudinal, observational, multi-centre study
Psychother Res. 2026 Apr 10:1-18. doi: 10.1080/10503307.2026.2650154. Online ahead of print.ABSTRACTOBJECTIVE: Psychotherapy research addressing emotional dysregulation and personality disorders (PDs) is mainly limited to borderline PD (BPD). This longitudinal study aimed to investigate dysregulation for a broader range of patients treated within PD treatment services and its associations with psychosocial impairment.…
Psychedelics as a potential treatment for borderline personality disorder: A narrative review
Psychiatry Res. 2026 Apr 2;361:117152. doi: 10.1016/j.psychres.2026.117152. Online ahead of print.ABSTRACTBorderline personality disorder (BPD) is a serious mental illness with high rates of morbidity and stigma; however, successful remission is frequently limited by a paucity of accessible treatment options. In an era of growing interest in psychedelics as novel psychiatric …
Dialectical Behavior Therapy vs Schema Therapy for Patients With Borderline Personality Disorder: The BOOTS Multicenter Randomized Clinical Trial
JAMA Psychiatry. 2026 Apr 22. doi: 10.1001/jamapsychiatry.2026.0418. Online ahead of print.ABSTRACTIMPORTANCE: Head-to-head comparisons of evidence-based treatments for borderline personality disorder (BPD), including dialectical behavior therapy (DBT) and schema therapy (ST), remain scarce, despite their widely recognized relevance.OBJECTIVE: To compare the effectiveness of DBT and ST in a multicenter trial among …
Long-term stability of perceived childhood trauma in individuals with borderline personality disorder
Eur J Psychotraumatol. 2026 Dec;17(1):2646755. doi: 10.1080/20008066.2026.2646755. Epub 2026 Apr 22.ABSTRACTBackground: The Childhood Trauma Questionnaire (CTQ) is a widely used tool for the retrospective assessment of childhood trauma (CT). However, evidence on its long-term stability remains limited, especially in diagnostically complex populations such as individuals with borderline personality disorder (BPD). Given the disorder's …
Wise Moments: A four-session Acceptance and Commitment Therapy for Borderline Personality Disorder
Australas Psychiatry. 2026 Apr 26:10398562261444297. doi: 10.1177/10398562261444297. Online ahead of print.ABSTRACTBackgroundBorderline Personality Disorder (BPD) is a complex mental health condition. Wise Moments is a four-session Acceptance and Commitment Therapy (ACT)-themed intervention for the preliminary treatment of BPD. It focuses on the ACT concept of the 'self-as-context' (the 'observing self'), encouraging the …
Impact of a one-day training session on borderline personality disorder on stigmatising attitudes and beliefs of health personnel
BMC Med Educ. 2026 May 1. doi: 10.1186/s12909-026-09256-x. Online ahead of print.ABSTRACTBACKGROUND: Borderline personality disorder (BPD) is highly stigmatized. Stigma, including clinicians' resistance, stigmatizing attitudes, and discriminatory beliefs, could be mitigated by a better knowledge of the disorder. This study evaluates the impact of a one-day training session …
Multidisciplinary team care and the challenges of borderline personality disorder
Australas Psychiatry. 2026 Apr 30:10398562261447774. doi: 10.1177/10398562261447774. Online ahead of print.ABSTRACTObjectiveThere are relatively few papers addressing the challenges faced in the care of people with Borderline Personality Disorder in healthcare systems. We therefore present a clinical perspective on multidisciplinary team management of Borderline Personality Disorder.ConclusionsBorderline Personality Disorder has historically attracted significant …
The Offender Personality Disorder Pathway for Men: Staff Perceptions About Possible Impact Re-offending in High-Risk Individuals with Personality Disorder
Int J Offender Ther Comp Criminol. 2026 May 7:306624X261449811. doi: 10.1177/0306624X261449811. Online ahead of print.ABSTRACTThe Offender Personality Disorder Pathway was introduced in England and Wales in 2012 to manage high risk offenders with personality disorder. One of the key outcomes of the Pathway is to reduce re-offending. A national mixed methods …
Peripheral immune and kynurenine profiles are associated with cognitive change during early treatment of first-episode schizophrenia
Front Psychiatry. 2026 Mar 25;17:1791018. doi: 10.3389/fpsyt.2026.1791018. eCollection 2026.ABSTRACTOBJECTIVE: To delineate the longitudinal relationships among peripheral inflammation, kynurenine pathway (KP) dysregulation, immune-cell redistribution, and cognitive performance in antipsychotic-naïve first-episode schizophrenia (FES).METHODS: Antipsychotic-naïve FES patients (n = 136) and healthy controls (HC; n = 136) were enrolled. FES received aripiprazole monotherapy through week 6, followed …
Changes in serum Nogo-A and BDNF levels following treatment in drug-naive first-episode schizophrenia: A naturalistic prospective study
Psychiatry Res. 2026 Apr 2;361:117149. doi: 10.1016/j.psychres.2026.117149. Online ahead of print.ABSTRACTBACKGROUND: Neuroplasticity dysregulation is implicated in the early pathophysiology of schizophrenia. Nogo-A, a myelin- and neuron-associated inhibitor of structural plasticity, has been less studied in first-episode schizophrenia (FES) than brain-derived neurotrophic factor (BDNF). This study examined short-term changes in serum …
Two patterns of abnormal FA with different radial features and their relation to polygenic risks in first-episode schizophrenia and unaffected siblings
J Psychiatr Res. 2026 Apr 7;198:275-285. doi: 10.1016/j.jpsychires.2026.04.004. Online ahead of print.ABSTRACTBACKGROUND: White matter microstructure abnormalities have been widely observed in schizophrenia, closely associated with clinical symptoms and cognitive deficits. While various alterations have been suggested, the nature of their specific patterns and underlying processes remains unclear. Thus, this …
A Twelve-Week Follow-up Study of Obesity, Antioxidant Enzyme Activity, and Clinical Symptoms in First-Episode Schizophrenia Patients Treated with Risperidone
Curr Neuropharmacol. 2026 Apr 9. doi: 10.2174/011570159X321613240902104936. Online ahead of print.ABSTRACTOBJECTIVE: Overweight/obesity is highly prevalent in schizophrenia (Sch), which can perturb brain function and correlate with symptom severity. An impaired antioxidant defense system is involved in the pathophysiology of Sch and obesity. This longitudinal study aimed to investigate the impact …
Association of plasma DISC1 levels with expression of negative symptoms of first-episode schizophrenia
Schizophr Res. 2026 May 1;294:133-139. doi: 10.1016/j.schres.2026.04.021. Online ahead of print.ABSTRACTThe Disrupted-in-Schizophrenia 1 (DISC1) gene and negative symptoms in schizophrenia are both implicated in neurodevelopmental abnormalities. However, their relationship remains unclear. Thus, this study aimed to compare plasma DISC1 levels and negative symptoms severity between first-episode schizophrenia (FDS) patients and …
Effect of transcranial alternating current stimulation on auditory verbal hallucinations in patients with treatment-resistant schizophrenia
Schizophr Res. 2026 Apr 6;293:72-80. doi: 10.1016/j.schres.2026.03.025. Online ahead of print.ABSTRACTBACKGROUND: Previous studies have demonstrated the potential of transcranial alternating current stimulation (tACS) to modulate auditory verbal hallucinations (AVH) in patients with schizophrenia (SZ) by regulating neural oscillations. However, the therapeutic efficacy of tACS for treatment-refractory AVH (TRAVH) remains …
Clozapine prescribing in treatment-resistant schizophrenia - an updated systematic literature review of barriers and facilitators among clinicians
Eur J Clin Pharmacol. 2026 Apr 11;82(5):119. doi: 10.1007/s00228-026-04046-2.ABSTRACTBACKGROUND: Increased rates of clozapine prescribing are essential to improving timely patient access within treatment-resistant schizophrenia (TRS) management. The extent of geographical variation in its use suggests it is possible to develop interventions to increase clinician engagement. To inform intervention …
Microstructural and diffusion tensor imaging of clozapine for treatment-resistant schizophrenia
Prog Neuropsychopharmacol Biol Psychiatry. 2026 Apr 14:111701. doi: 10.1016/j.pnpbp.2026.111701. Online ahead of print.ABSTRACTBACKGROUND: Clozapine (CLZ) demonstrates superior efficacy for treatment-resistant schizophrenia (TRS), but mechanisms underlying its effects remain unknown. Pathophysiologic links between cortical regions and the basal ganglia (BG) characterize schizophrenia and are implicated in the mechanism of CLZ's action. …
Cognitive behavioral therapy for insomnia vs. standard cognitive behavioral therapy for sleep and circadian disturbances in treatment-resistant schizophrenia: study protocol for the randomized controlled trial (COSTS)
Trials. 2026 Apr 17;27(1):309. doi: 10.1186/s13063-026-09482-0.ABSTRACTBACKGROUND: A subset of patients with schizophrenia do not respond sufficiently to conventional antipsychotic treatment and often have a more complex clinical course, including high rates of sleep disturbances, which can contribute to further worsening of symptoms. However, sleep disturbances are often overlooked …
Deep brain stimulation for clozapine-resistant schizophrenia: a systematic review of target-specific outcomes and stereotactic technical considerations
Neurosurg Rev. 2026 May 2;49(1):389. doi: 10.1007/s10143-026-04296-9.ABSTRACTTreatment-resistant schizophrenia (TRS) affects approximately 20-30% of patients, and a substantial proportion develop clozapine-resistant schizophrenia (CRS). Deep brain stimulation (DBS) has emerged as a potential neurosurgical intervention targeting dysfunctional cortico-striato-limbic circuitry. However, technical heterogeneity and limited clinical data constrain interpretation of outcomes. …
Transitioning from clozapine to Cobenfy (xanomeline-trospium chloride) in treatment resistant schizophrenia and clozapine induced OCD
BMC Psychiatry. 2026 May 2. doi: 10.1186/s12888-026-07795-7. Online ahead of print.ABSTRACTBACKGROUND: Treatment-resistant schizophrenia (TRS) is defined as nonresponse to at least two adequate antipsychotic trials at therapeutic doses for six or more weeks. Currently, clozapine is the only antipsychotic approved for TRS by the FDA and a plethora …
Cutaneous Small Vessel Vasculitis Secondary to Clozapine Use in a 22-Year-Old Man With Treatment-Resistant Schizophrenia
Cureus. 2026 Apr 4;18(4):e106430. doi: 10.7759/cureus.106430. eCollection 2026 Apr.ABSTRACTClozapine is the most effective drug for treatment-resistant schizophrenia (TRS) but is associated with several adverse effects, including rare immune-mediated reactions. Cutaneous small vessel vasculitis (CSVV), also known as leukocytoclastic vasculitis, is an uncommon complication that typically presents as palpable purpura involving dependent …
Recurrent violent behavior following medication discontinuation in chronic schizophrenia: A longitudinal forensic case report
J Forensic Sci. 2026 Apr 12. doi: 10.1111/1556-4029.70333. Online ahead of print.ABSTRACTViolence associated with schizophrenia is typically restricted to a small proportion of patients experiencing acute psychosis, impaired insight, or abrupt discontinuation of antipsychotic medication. Longitudinal forensic cases demonstrating recurrent severe violence across multiple decades are rarely documented. This report describes …
Psychothérapies pour le trouble bipolaire et la dépression
The effectiveness of Parenthood-Centred Psychotherapy on perinatal maternal depressive-anxiety symptoms and child development in a disadvantaged population
Front Psychol. 2026 Mar 25;17:1758157. doi: 10.3389/fpsyg.2026.1758157. eCollection 2026.ABSTRACTINTRODUCTION: Untreated depressive-anxiety symptoms during pregnancy can lead to recurrent or chronic maternal depression, with negative consequences for child development and the mother-infant bond. The hypothesis is that Parenthood-Centred Psychotherapy reduces depressive-anxiety symptoms and promotes the mother-infant bond in a disadvantaged population, with high …
Negative effects of mindfulness-based cognitive therapy and cognitive behavioural analysis system of psychotherapy for patients with 'difficult to treat' depression: protocol for a systematic review and individual participant data meta-analysis
BMJ Open. 2026 Apr 16;16(4):e106362. doi: 10.1136/bmjopen-2025-106362.ABSTRACTINTRODUCTION: Mindfulness-based interventions are widely used, yet concerns about potential negative effects-particularly those related to mindfulness meditation practice-have gained increasing attention. Individuals with difficult-to-treat depression (DTD) represent a population of particular relevance due to heightened vulnerability, but comparative evidence on clinically relevant negative …
Does attachment change serve as a theory-specific mediator of depression reduction in interpersonal psychotherapy versus cognitive behavioral therapy?
Psychother Res. 2026 Apr 16:1-14. doi: 10.1080/10503307.2026.2656698. Online ahead of print.ABSTRACTOBJECTIVE: Although interpersonal psychotherapy (IPT) and cognitive behavioral therapy (CBT) for depression are comparably efficacious, less is known about the respective patient-level processes that help transmit their beneficial effect. Given its explicit and primary focus on attachment theory and relationship processes, …
Facilitators and Barriers to the Utilization of Psychotherapeutic and Psychiatric Services among Men with Depression - A Qualitative Interview Study
Psychother Psychosom Med Psychol. 2026 Apr 23. doi: 10.1055/a-2842-9225. Online ahead of print.ABSTRACTOBJECTIVE: Men with depression are underrepresented in psychiatric and psychotherapeutic care, despite their increased risk of suicide. Studies point to the influence of traditional masculinity norms, stigma-related attitudes, and gender-specific coping patterns on help-seeking behavior. However, it remains …
Methodological Considerations for Comorbidity of Anxiety and Depression in Later-Life Psychotherapy Trials: A Scoping Review
Clin Gerontol. 2026 Apr 27:1-14. doi: 10.1080/07317115.2026.2661906. Online ahead of print.ABSTRACTOBJECTIVES: Anxiety and depression are highly comorbid in older adults, especially considering subthreshold symptom presentations. Psychotherapies treating both conditions in this population are not well established. This scoping review aimed to quantify how frequently psychotherapy trials for anxiety/depression in older …
Lifestyle and psychotherapy interventions for older adults with bipolar disorder
Curr Opin Psychiatry. 2026 Apr 30. doi: 10.1097/YCO.0000000000001092. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Bipolar disorder (BD) in older adults presents unique clinical challenges, and nonpharmacological interventions are an important component of comprehensive care, with more favorable side-effect profiles. This review synthesizes recent evidence on lifestyle and psychotherapy interventions for older …
Applicable Scenarios, Desired Features, and Risks of AI Psychotherapists in Depression Treatment From the Patient's Perspective: Exploratory Qualitative Study
JMIR Form Res. 2026 May 1;10:e85138. doi: 10.2196/85138.ABSTRACTBACKGROUND: Depression is a pervasive global mental health issue, yet access to trained professionals remains severely limited. With the rapid advancement of artificial intelligence (AI), digital tools are increasingly seen as a viable way to address this shortage. However, questions remain about how digital …
Avoidant Personality Traits and Avoidant Coping in Cognitive-Behavioral Therapy vs. Short-Term Psychodynamic Psychotherapy for Adult Depression
Personal Ment Health. 2026 May;20(2):e70081. doi: 10.1002/pmh.70081.ABSTRACTResearch on the significance of comorbid personality disorders (PD) on the outcome of depression treatment has shown inconsistent findings. In addition, it is still unclear whether treatment choice based on personality traits and coping can enhance the efficacy of depression treatment. Aiming to …
The Impact of Family Factors on Adolescent Intensive Outpatient Psychotherapy Outcomes for Suicidal Thoughts, Behaviors, and Depression
Suicide Life Threat Behav. 2026 Jun;56(3):e70104. doi: 10.1111/sltb.70104.ABSTRACTBACKGROUND: Although they constitute well-established risk factors for suicidal thoughts and behaviors (STBs), few studies have investigated how family factors such as family cohesion and family conflict influence the trajectory of treatment response among depressed and suicidal adolescents. In this study, we …